Retinoic acid stimulates degradation of interstitial collagen fibrils by rat mucosal keratinocytes in vitro.


A large body of evidence suggests that retinoids modulate the phenotypic expression of epithelial cells of skin and mucous membranes. The purpose of this study was to investigate the effect of retinoic acid on keratinocyte-mediated collagen breakdown. Keratinocytes derived from the ventral surfaces of the tongues of 4-6 week-old male Wistar rats were… (More)


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