Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells.

@article{Lee1995RetinoicAS,
  title={Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells.},
  author={You-Jin Lee and Noriko Osumi-Yamashita and Yoshifumi Ninomiya and Chang Kiu Moon and Ulf Eriksson and Kazuhiro Eto},
  journal={Development},
  year={1995},
  volume={121 3},
  pages={825-37}
}
This study investigates the migration patterns of cranial neural crest cells in retinoic acid (RA)-treated rat embryos using DiI labeling. Wistar-Imamichi rat embryos were treated at the early (9.0 days post coitum, d.p.c.) and late (9.5 d.p.c.) neural plate stages with all-trans RA (2 x 10(-7) M) for 6 hours and further cultured in an RA-free medium. RA exposure stage dependently induced two typical craniofacial abnormalities; that is, at 9.0 d.p.c. it reduced the size and shape of the first… CONTINUE READING