Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-alpha.

@article{Li1994RetinoicAH,
  title={Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-alpha.},
  author={Yan Li and Fatimah Said and Robert E. Gallagher},
  journal={Blood},
  year={1994},
  volume={83 11},
  pages={3298-302}
}
Sequence analysis of the retinoic acid receptor-alpha (RAR alpha) gene from a subline of HL-60 cells (RA-res) stably resistant to all-trans retinoic acid (RA) disclosed a single-base change in codon number 411, the same C to T transition previously reported in an independently selected HL-60 RA resistant clone by Robertson et al (Blood 80:1885, 1992). This mutation eliminates a FokI restriction endonuclease site. Using primers framing this mutation in exon 9 of the RAR alpha gene, we showed… CONTINUE READING
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