Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.

@article{Wang2006RetinoicAR,
  title={Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.},
  author={Zengxin Wang and Pascal Doll{\'e} and Wellington V Cardoso and Karen Niederreither},
  journal={Developmental biology},
  year={2006},
  volume={297 2},
  pages={
          433-45
        }
}
  • Zengxin Wang, Pascal Dollé, +1 author Karen Niederreither
  • Published in Developmental biology 2006
  • Medicine, Biology
  • Retinoic acid (RA) is an embryonic signaling molecule regulating a wide array of target genes, thereby being a master regulator of patterning and differentiation in a variety of organs. Here we show that mouse embryos deficient for the RA-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2), if rescued from early lethality by maternal RA supplementation between E7.5 and E8.5, lack active RA signaling in the foregut region. The resulting mutants completely fail to develop lungs… CONTINUE READING

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