Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1.

@article{Sheng2010RetinoicAR,
  title={Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1.},
  author={Nengyin Sheng and Zhihui Xie and Chen Wang and Ge Bai and Kejing Zhang and Qingqing Zhu and Jianguo Song and François Guillemot and Ye-Guang Chen and Anning Lin and Naihe Jing},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 44},
  pages={18886-91}
}
The proper function of the bone morphogenic protein (BMP) pathway during embryonic development and organ maintenance requires its communication with other signaling pathways. Unlike the well-documented regulation of the BMP pathway by FGF/MAPK and Wnt/GSK3 signals, cross-talk between BMP/Smad and retinoic acid (RA)/RA receptor (RAR) pathways is poorly understood. Here, we show that RA represses BMP signal duration by reducing the level of phosphorylated Smad1 (pSmad1). Through its nuclear… CONTINUE READING
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