Retinoic acid receptors and cancers.

  title={Retinoic acid receptors and cancers.},
  author={Dianne Robert Soprano and Pu Qin and Kenneth J. Soprano},
  journal={Annual review of nutrition},
Studies utilizing experimental animals, epidemiological approaches, cellular models, and clinical trials all provide evidence that retinoic acid and some of its synthetic derivatives (retinoids) are useful pharmacological agents in cancer therapy and prevention. In this chapter, we first review the current knowledge of retinoic acid receptors (RARs) and their role in mediating the actions of retinoic acid. We then focus on a discussion of RARalpha and acute promyelocytic leukemia followed by a… CONTINUE READING
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