Retinoic acid receptors: from molecular mechanisms to cancer therapy.

@article{Masi2015RetinoicAR,
  title={Retinoic acid receptors: from molecular mechanisms to cancer therapy.},
  author={Alessandra di Masi and Loris Leboffe and Elisabetta De Marinis and Francesca Pagano and Laura Cicconi and C{\'e}cile Rochette-Egly and Francesco Lo-Coco and Paolo Ascenzi and Clara Nervi},
  journal={Molecular aspects of medicine},
  year={2015},
  volume={41},
  pages={1-115}
}
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pleiotropic effects in cell growth and differentiation that are relevant for embryonic development and adult physiology. The RA activity is mediated primarily by members of the retinoic acid receptor (RAR) subfamily, namely RARα, RARβ and RARγ, which belong to… CONTINUE READING