Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.

@article{Galdones2008RetinoicAR,
  title={Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.},
  author={Eugene Galdones and B. Hales},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 1},
  pages={
          223-32
        }
}
  • Eugene Galdones, B. Hales
  • Published 2008
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
Vitamin A derivatives modulate gene expression through retinoic acid and rexinoid receptor (RAR/RXR) heterodimers and are indispensable for limb development. Of particular interest, RARgamma is highly expressed in cartilage, a target affected following retinoid-induced limb insult. The goal of this study was to examine how selective activation of RARgamma affects limb development. Forelimbs from E12.5 CD-1 mice were cultured for 6 days in the presence of all-trans RA (pan-RAR agonist; 0.1 or 1… Expand
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