Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.

@article{Galdones2008RetinoicAR,
  title={Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.},
  author={Eugene Galdones and B. Hales},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 1},
  pages={
          223-32
        }
}
  • Eugene Galdones, B. Hales
  • Published 2008
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
Vitamin A derivatives modulate gene expression through retinoic acid and rexinoid receptor (RAR/RXR) heterodimers and are indispensable for limb development. Of particular interest, RARgamma is highly expressed in cartilage, a target affected following retinoid-induced limb insult. The goal of this study was to examine how selective activation of RARgamma affects limb development. Forelimbs from E12.5 CD-1 mice were cultured for 6 days in the presence of all-trans RA (pan-RAR agonist; 0.1 or 1… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors.
  • 34
Role of retinoic acid receptors alpha1 and gamma in the response of murine limbs to retinol in vitro.
  • 5
Role of retinoic acid receptors α1 and γ in the response of murine limbs to retinol in vitro
  • 6
Novel retinoid targets in the mouse limb during organogenesis.
  • Sarah E Ali-Khan, B. Hales
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2006
  • 17
  • PDF
Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.
  • 59
Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse
  • 403
Retinoic acid induces matrix Gla protein gene expression in human cells.
  • 65
  • PDF
PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.
  • 42
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.
  • 683
  • Highly Influential
  • PDF
Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene.
  • 50
  • PDF
...
1
2
3
4
5
...