Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells.

@article{Zhang2007RetinoicAR,
  title={Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells.},
  author={Zhongming Zhang and Keiichiro Joh and Hitomi Yatsuki and Wei Zhao and Hidenobu Soejima and Ken Higashimoto and Mitsuyo Noguchi and Masatoshi Yokoyama and Tsuyoshi Iwasaka and Tsunehiro Mukai},
  journal={Cancer letters},
  year={2007},
  volume={247 2},
  pages={318-27}
}
To elucidate the silencing mechanism of retinoic acid receptor beta2 (RAR beta2) in cervical carcinogenesis, we investigated RAR beta2 expression and the status of both DNA methylation and histone modifications at the promoter in cervical cancer cell lines. RAR beta2 was frequently repressed in cancer cell lines and in primary cancers of the cervix… CONTINUE READING