Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice.

@article{Yanagitani2004RetinoicAR,
  title={Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice.},
  author={Atsushi Yanagitani and Sadako Yamada and Sakiko Yasui and Takashi Shimomura and Rie Murai and Yoshiyuki Murawaki and Koichi Hashiguchi and Takamasa Kanbe and Toshiya Saeki and Miho Ichiba and Yoshitada Tanabe and Yoko Yoshida and Shin-Ichi Morino and Akihiro Kurimasa and Nobumitsu Usuda and Hidetoshi Yamazaki and Takahiro Kunisada and Hisao Ito and Yoshikazu Murawaki and Goshi Shiota},
  journal={Hepatology},
  year={2004},
  volume={40 2},
  pages={
          366-75
        }
}
Although attention has focused on the chemopreventive action of retinoic acid (RA) in hepatocarcinogenesis, the functional role of RA in the liver has yet to be clarified. To explore the role of RA in the liver, we developed transgenic mice expressing RA receptor (RAR) alpha- dominant negative form in hepatocytes using albumin promoter and enhancer. At 4 months of age, the RAR alpha- dominant negative form transgenic mice developed microvesicular steatosis and spotty focal necrosis… CONTINUE READING
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