Retinoic acid receptor γ-dependent signaling cooperates with BMP2 to induce osteoblastic differentiation of C2C12 cells.

@article{Karakida2011RetinoicAR,
  title={Retinoic acid receptor γ-dependent signaling cooperates with BMP2 to induce osteoblastic differentiation of C2C12 cells.},
  author={Takeo Karakida and Ryogo Yui and Toshiaki Suzuki and Makoto Fukae and Shinichiro Oida},
  journal={Connective tissue research},
  year={2011},
  volume={52 5},
  pages={365-72}
}
All-trans retinoic acid and bone morphogenetic protein 2 (BMP2) synergistically induced an alkaline phosphatase (ALP) activity, one of the osteoblastic differentiation markers, and promoted the extracellular matrix calcification in a myoblastic C2C12 cell culture system. The induced ALP mRNA was not suppressed in the presence of a protein synthesis… CONTINUE READING