Retinoic acid receptor β2 promotes functional regeneration of sensory axons in the spinal cord

@article{Wong2006RetinoicAR,
  title={Retinoic acid receptor β2 promotes functional regeneration of sensory axons in the spinal cord},
  author={Liang-Fong Wong and Ping Kei Yip and A. Battaglia and John Grist and Jonathan P.T. Corcoran and Malcolm Maden and Mimoun Azzouz and Susan M. Kingsman and Alan J. Kingsman and Nicholas D Mazarakis and Stephen B. McMahon},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={243-250}
}
The embryonic CNS readily undergoes regeneration, unlike the adult CNS, which has limited axonal repair after injury. Here we tested the hypothesis that retinoic acid receptor β2 (RARβ2), critical in development for neuronal growth, may enable adult neurons to grow in an inhibitory environment. Overexpression of RARβ2 in adult rat dorsal root ganglion cultures increased intracellular levels of cyclic AMP and stimulated neurite outgrowth. Stable RARβ2 expression in DRG neurons in vitro and in… CONTINUE READING