Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR.

@article{Li2018RetinoicAP,
  title={Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR.},
  author={Xiaofeng Li and K. L. B. Fok and Jinghui Guo and Yan Wang and Zhenqing Liu and Ziyi Chen and Chengdong Wang and Ye Chun Ruan and Sidney Siubun Yu and Hui Zhao and Ji Wu and X. H. Jiang and Hsiao Chang Chan},
  journal={Biochimica et biophysica acta},
  year={2018},
  volume={1865 4},
  pages={605-615}
}
Retinoic acid (RA) plays a pivotal role in many cellular processes; however, the signaling mechanisms mediating the effect of RA are not fully understood. Here, we show that RA transcriptionally upregulates cystic fibrosis transmembrane conductance regulator (Cftr) by promoting the direct binding of its receptor RARα to Cftr promoter in mouse spermatogonia… CONTINUE READING
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