Retinoic acid-producing, ex-vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes.

@article{Caro2013RetinoicAE,
  title={Retinoic acid-producing, ex-vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes.},
  author={Valentina Di Caro and Brett Eugene Phillips and Carl L Engman and J. B. Harnaha and M. Alejandra Trucco and Nick Giannoukakis},
  journal={Clinical and experimental immunology},
  year={2013},
  volume={174 2},
  pages={
          302-17
        }
}
While much is known about tolerogenic dendritic cell effects on forkhead box protein 3 (FoxP3)⁺ regulatory T cells, virtually nothing is known about their effects on another arm of immunoregulation that is mediated by a subpopulation of immunosuppressive B cells. These cells suppress rheumatoid arthritis, lupus and inflammatory bowel disease in mice, and functional defects have been reported in human lupus. We show that co-stimulation-impaired tolerogenic dendritic cells that prevent and… CONTINUE READING
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