Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells

@article{YokotaNakatsuma2014RetinoicAP,
  title={Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells},
  author={Aya Yokota-Nakatsuma and Hideyuki Takeuchi and Yoshiharu Ohoka and Chikaki Kato and S-Y Song and Tomoaki Hoshino and H. Yagita and Toshiaki Ohteki and Makoto Iwata},
  journal={Mucosal Immunology},
  year={2014},
  volume={7},
  pages={786-801}
}
The vitamin A (VA) metabolite retinoic acid (RA) affects the properties of T cells and dendritic cells (DCs). In VA-deficient mice, we observed that mesenteric lymph node (MLN)-DCs induce a distinct inflammatory T helper type 2 (Th2)-cell subset that particularly produces high levels of interleukin (IL)-13 and tumor necrosis factor-α (TNF-α). This subset expressed homing receptors for skin and inflammatory sites, and was mainly induced by B220−CD8α−CD11b+CD103− MLN-DCs in an IL-6- and OX40… CONTINUE READING
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