Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation.

@article{Gaetano1991RetinoicAN,
  title={Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation.},
  author={Carlo Gaetano and Kunihiro Matsumoto and Carol J. Thiele},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1991},
  volume={2 10},
  pages={487-93}
}
p34cdc2 is a protein kinase that has an important role in controlling cell cycle progression and may regulate tumor suppressor gene activity. In this work, we show that the arrest of cell growth and induction of differentiation in a tumorigenic neuroblastoma cell line by retinoic acid (RA) is associated with a 75-fold decrease in the level of p34cdc2 protein. The RA induced decrease in p34cdc2 levels does not simply reflect the arrest of cell growth, because p34cdc2 levels are not reduced when… CONTINUE READING

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