Retinoic acid modulation of mRNA levels in malignant, nontransformed, and immortalized osteoblasts.

@article{Zhou1991RetinoicAM,
  title={Retinoic acid modulation of mRNA levels in malignant, nontransformed, and immortalized osteoblasts.},
  author={Hong Zhou and R. Glenn Hammonds and David M. Findlay and Peter J. Fuller and Thomas J Martin and Kong Wah Ng},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1991},
  volume={6 7},
  pages={767-77}
}
Clonal cell lines presumably "arrested" at a particular stage of differentiation are useful models to study the processes of differentiation in osteoblasts. UMR-201 is a presumptive preosteoblastic nontransformed rat clonal cell line with a limited life span in culture. Two immortalized cell lines, UMR-201-10A (10A) and UMR-201-10B (10B), were derived from UMR-201 by stable transfection with simian virus (SV) 40 large T antigen. This study compares the growth and profile of gene expression of… CONTINUE READING