Retinoic acid modulates prolactin receptor expression and prolactin-induced STAT-5 activation in breast cancer cells in vitro

@article{Widschwendter1999RetinoicAM,
  title={Retinoic acid modulates prolactin receptor expression and prolactin-induced STAT-5 activation in breast cancer cells in vitro},
  author={Martin Widschwendter and Andreas Widschwendter and Tobias Welte and Guenter Daxenbichler and Alain Gustave Zeimet and A. M. Bergant and Jennifer Berger and J-P Peyrat and Schneider Michel and Wolfgang Doppler and Ch. Marth},
  journal={British Journal of Cancer},
  year={1999},
  volume={79},
  pages={204 - 210}
}
SummaryTwo recent papers demonstrate that prolactin plays an important role in the induction and progression of mammary tumours. Retinoids have been shown to be potent inhibitors of breast carcinogenesis. We studied expression of prolactin receptor mRNA in human breast cancer cell lines MCF-7, SKBR-3, T47D and BT-20 treated with and without retinoids using Northern blot and a quantitative polymerase chain reaction (PCR) method. In all cell lines, all-trans- and 9-cis-retinoic acid, as well as… CONTINUE READING

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Regulation of Prolactin Receptor Levels and Activity in Breast Cancer

  • Journal of Mammary Gland Biology and Neoplasia
  • 2008
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