Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study.

@article{Arantes2019RetinoicAS,
  title={Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study.},
  author={Valqu{\'i}ria T Arantes and A. A. G. Faraco and Frederico B Ferreira and C. A. Oliveira and Elis{\^a}ngela Martins-Santos and Puebla Cassini-Vieira and L. Barcelos and L. A. Ferreira and Gisele A. C. Goulart},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2019},
  volume={188},
  pages={
          110749
        }
}
Repair of tissue damaged in diabetic wounds is essential to minimize the cases of amputation of the limbs in millions of diabetic people around the world. Although the all-trans retinoic acid (ATRA) is described as a potential wound healing agent, however its effects are controversial due to adverse reactions that may impair the wound healing during the treatment schedules. Our aim was to design and characterize an ATRA-loaded solid lipid nanoparticles surrounded by chitosan film to promote an… Expand
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