Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway.

@article{Percario1999RetinoicAI,
  title={Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway.},
  author={Zulema Antonia Percario and Valeria Giandomenico and Gianna Fiorucci and Maria Vincenza Chiantore and Serena Vannucchi and John Hiscott and Elisabetta Affabris and Giovanna Romeo},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1999},
  volume={10 4},
  pages={263-70}
}
Interferon regulatory factor 1 (IRF-1) transcription factor binds to DNA sequence elements found in the promoters of type I IFN and IFN-inducible genes. Transient up-regulation of the IRF-1 gene by virus and IFN treatment causes the consequent induction of many IFN-inducible genes involved in cell growth control and apoptosis. We reported recently that IFN-alpha and all-trans retinoic Acid (RA) inhibit the cell proliferation of squamous carcinoma cell line ME-180 by inducing apoptotic cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Retinoids inhibit measles virus through a type I IFN-dependent bystander effect.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2009

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Retinoic acid and IFN inhibition of cell proliferation is associated with apoptosis in squamous carcinoma cell lines: role of IRF-1 and TGase II-dependent pathways.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research • 1997
View 8 Excerpts

Similar Papers

Loading similar papers…