Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.

@article{Hendrix1990RetinoicAI,
  title={Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.},
  author={Mary J. C. Hendrix and Wallace R. Wood and Elisabeth A. Seftor and Dafna Lotan and Motowo Nakajima and Ronald L. Misiorowski and Richard E. B. Seftor and William G Stetler-Stevenson and S J Bevacqua and Lance A. Liotta},
  journal={Cancer research},
  year={1990},
  volume={50 13},
  pages={4121-30}
}
Treatment of four A375 human melanoma sublines (A375, A375P, A375P-5, A375M), exhibiting distinct metastatic potentials in vivo, with beta-all-trans-retinoic acid in vitro caused a dose- and time-dependent inhibition of the ability of these cells to penetrate Matrigel-coated filters using a reconstituted basement membrane invasion assay. The possible mechanisms of action responsible for the antiinvasive effect were further investigated, and the data showed that compared with untreated cells the… CONTINUE READING

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