Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3.

@article{Holm2007RetinoicAG,
  title={Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3.},
  author={Geoffrey H Holm and Jennifer Zurney and Vanessa Fonseca Tumilasci and Simon Leveille and Pranav Danthi and John Hiscott and Barbara Sherry and Terence S Dermody},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 30},
  pages={21953-61}
}
During viral infection, cells initiate antiviral responses to contain replication and inhibit virus spread. One protective mechanism involves activation of transcription factors interferon regulatory factor-3 (IRF-3) and NF-kappaB, resulting in secretion of the antiviral cytokine, interferon-beta. Another is induction of apoptosis, killing the host cell before virus disseminates. Mammalian reovirus induces both interferon-beta and apoptosis, raising the possibility that both pathways are… CONTINUE READING
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