Retinoic acid induces prostatic bud formation.

  title={Retinoic acid induces prostatic bud formation.},
  author={Chad M Vezina and Sarah Hicks Allgeier and Wayne A Fritz and Robert W. Moore and Michael Strerath and Wade Bushman and Richard Einer Peterson},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={237 5},
Formation of prostatic buds from the urogenital sinus (UGS) to initiate prostate development requires localized action of several morphogenetic factors. This report reveals all-trans-retinoic acid (RA) to be a powerful inducer of mouse prostatic budding that is associated with reciprocal changes in expression of two regulators of budding: sonic hedgehog (Shh) and bone morphogenetic protein 4 (Bmp4). Localization of retinoid signaling and expression of RA synthesis, metabolism, and receptor… CONTINUE READING


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Retinoic acid induced cardiotoxicity in the zebrafish embryo: microarray studies identify Nr2f5 as a critical target

J Chen, SA Carney, RE Peterson, W. Heideman
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