Retinoic acid induces neuroblastoma cell death by inhibiting proteasomal degradation of retinoic acid receptor alpha.

Abstract

To seek a novel therapeutic approach to neuroblastoma (NBL), we used three NBL cell lines (SK-N-DZ, NH12, and SK-N-SH) to examine the underlining molecular mechanisms of cellular reactions and sensitivity to all-trans-retinoic acid (ATRA). SK-N-DZ cells expressed relatively high levels of retinoic acid receptor alpha (RAR-alpha) and underwent ATRA-induced… (More)

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@article{Nagai2004RetinoicAI, title={Retinoic acid induces neuroblastoma cell death by inhibiting proteasomal degradation of retinoic acid receptor alpha.}, author={Jun-ichi Nagai and Takuya Yazawa and Koji Okudela and Hisato Kigasawa and Hitoshi Kitamura and Hitoshi Osaka}, journal={Cancer research}, year={2004}, volume={64 21}, pages={7910-7} }