Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice.

@article{Zhou2015RetinoicAI,
  title={Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice.},
  author={Wenjing Zhou and Jiacheng Lin and Hongen Chen and Jingjing Wang and Yan Liu and Min Xia},
  journal={The British journal of nutrition},
  year={2015},
  volume={114 4},
  pages={509-18}
}
It has been suggested that retinoic acid (RA) has a potential role in the prevention of atherosclerotic CVD. In the present study, we used J774A.1 cell lines and primary peritoneal macrophages to investigate the protective effects of RA on foam cell formation and atherogenesis in apoE-deficient (apoE- / -) mice. A total of twenty male apoE- / - mice (n 10 animals per group), aged 8 weeks, were fed on a high-fat diet (HFD) and treated with vehicle or 9-cis-RA for 8 weeks. The atherosclerotic… CONTINUE READING
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