Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice.

Abstract

Diarrheal diseases represent a major health burden in developing countries. Parenteral immunization typically does not induce efficient protection against enteropathogens because it does not stimulate migration of immune cells to the gut. Retinoic acid (RA) is critical for gut immunity, inducing upregulation of gut-homing receptors on activated T cells. In… (More)
DOI: 10.1172/JCI44262

Topics

5 Figures and Tables