Retinoic acid induced myelomeningocele in fetal rats: characterization by histopathological analysis and magnetic resonance imaging.

@article{Danzer2005RetinoicAI,
  title={Retinoic acid induced myelomeningocele in fetal rats: characterization by histopathological analysis and magnetic resonance imaging.},
  author={Enrico Danzer and Uwe Schwarz and Suzanne W Wehrli and Antoneta Radu and N. Scott Adzick and Alan W. Flake},
  journal={Experimental neurology},
  year={2005},
  volume={194 2},
  pages={467-75}
}
The prevention of human neural tube defects by folic acid administration and the potential for fetal surgical intervention for myelomeningocele (MMC) have renewed interest in the molecular pathways and pathophysiology of spina bifida. Animal models for assessment of the early developmental biology and pathophysiology of this lesion are needed. The goal of this study was to develop and characterize a non-surgical rat model of MMC. Time-dated Sprague-Dawley rats were gavage fed different doses of… CONTINUE READING
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