Retinoic acid-induced inner ear teratogenesis caused by defective Fgf3/Fgf10-dependent Dlx5 signaling.

@article{Liu2008RetinoicAI,
  title={Retinoic acid-induced inner ear teratogenesis caused by defective Fgf3/Fgf10-dependent Dlx5 signaling.},
  author={Wei Liu and Giovanni Levi and Alan Lawrence Shanske and Dorothy A. Frenz},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2008},
  volume={83 2},
  pages={
          134-44
        }
}
BACKGROUND Retinoic acid (RA) is essential for inner ear development. However, exposure to excess RA at a critical period leads to inner ear defects. These defects are associated with disruption in epithelial-mesenchymal interactions. METHODS This study investigates the role of Dlx5 in the epithelial-mesenchymal interactions that guide otic capsule chondrogenesis, as well as the effect of excess in utero RA exposure on Dlx5 expression in the developing mouse inner ear. Control of Dlx5 by Fgf3… CONTINUE READING

Citations

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Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.

  • American journal of medical genetics. Part A
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