Retinoic acid induced HL-60 myeloid differentiation: dependence of early and late events on isomeric structure.

@article{Yen1986RetinoicAI,
  title={Retinoic acid induced HL-60 myeloid differentiation: dependence of early and late events on isomeric structure.},
  author={Andrew C. Yen and V. Michael Powers and J. K. Fishbaugh},
  journal={Leukemia research},
  year={1986},
  volume={10 6},
  pages={
          619-29
        }
}
The capability of HL-60 cells to undergo G1/0 specific growth arrest and myeloid differentiation in response to isomers of retinoic acid (RA) having an altered alkyl chain was determined. At a concentration where beta-all trans RA induces myeloid differentiation and G1/0 specific growth arrest, 11,13-dicis and 9,13-dicis isomers failed to induce significant phenotypic differentiation, assayed by the inducible superoxide production characteristic of mature myeloid cells, but could induce… CONTINUE READING
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