Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells.

@article{Sonneveld1999RetinoicAH,
  title={Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells.},
  author={Edwin Sonneveld and Christina E van den Brink and Leon G.J Tertoolen and Bart van der Burg and Paul T. van der Saag},
  journal={Developmental biology},
  year={1999},
  volume={213 2},
  pages={390-404}
}
Besides nuclear retinoid receptors and cellular retinoid binding proteins also retinoic acid (RA)-synthesizing enzymes (using all-trans-retinal as substrate) and RA-catabolizing enzymes (producing hydroxylated products) may explain the specific effects of retinoids. In the past we have established an active role for 4-hydroxy-RA and 4-oxo-RA, which originally were considered to be inactive retinoids, but in fact are highly active modulators of positional specification in Xenopus development… CONTINUE READING

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