Retinoic acid effects on endothelial cell function: interaction with interleukin 1.

  title={Retinoic acid effects on endothelial cell function: interaction with interleukin 1.},
  author={George T Spencer-Green},
  journal={Clinical immunology and immunopathology},
  volume={72 1},
  • G. Spencer-Green
  • Published 1 July 1994
  • Biology, Medicine
  • Clinical immunology and immunopathology
Blood vessel angiogenesis is an important component of chronic synovitis, and its regulation may be mediated through local production and effects of certain inflammatory cytokines, including interleukin-1 (IL-1). Retinoic acid (RA) can alter the progression of some inflammatory arthritic diseases, presumably through effects on fibroblast collagenase and PGE2 production. To explore alternate hypotheses, we examined the interaction of retinoic acid and IL-1 on endothelial cell (EC) function and… 
Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines.
Results indicate that normal, differentiated cell types differ in their ability to esterify retinol, and suggest that retinoid-deficiency in the tumor cells could develop because of the lack of retinyl esters, a storage form ofretinol.
Gene Polymorphisms for PAI-1 Are Associated with the Angiographic Extent of Coronary Artery Disease
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The Inhibitors of the Fibrinolytic System
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Vitamin A deficiency changes jejunal mucosal fatty acid profile in rats
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Lecithin: Retinol acyltransferase and retinyl esters—is balance the essence in carcinogenesis?
  • R. Ghosh
  • Biology
    Cancer biology & therapy
  • 2009
Overexpression of lecithin in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen.
Vitamin A status and inflammation during the first week of life in extremely premature infants at risk for bronchopulmonary dysplasia.
The research on vitamin A supplementation for premature infants, as well as the issues and clinical implications associated with this intervention, are reviewed.
The effects of vitamin A supplementation on the production of hypersensitive inflammatory mediators of ammonia-induced airways of pigs
Exposure to ammonia produces a disruptive defect in the lungs and vitamin A supplementation may relieve this detriment by modulating the production of pulmonary inflammatory mediators.
Retinoic acid and lipopolysaccharide act synergistically to increase prostanoid concentrations in rats in vivo.
In vivo, RA and LPS increased PG and especially PGE(2) concentrations, associated with NOS2-mediated activation of COX and induction of mPGES, and contribute to the characterization of the effects of vitamin A on the host inflammatory response.
Gene polymorphisms for plasminogen activator inhibitor-1/tissue plasminogen activator and development of allograft coronary artery disease.
These data suggest that recipients with a 2/2 PAI-1 genotype are at a significant risk of developing Tx CAD, and this genotype may serve as a useful screening tool for predicting the future development of TX CAD.