Retinoic acid effects on an SV‐40 large T antigen immortalized adult rat bone cell line

@article{LafageProust1999RetinoicAE,
  title={Retinoic acid effects on an SV‐40 large T antigen immortalized adult rat bone cell line},
  author={M. Lafage-Proust and G. Wesolowski and M. Ernst and G. Rodan and S. Rodan},
  journal={Journal of Cellular Physiology},
  year={1999},
  volume={179}
}
  • M. Lafage-Proust, G. Wesolowski, +2 authors S. Rodan
  • Published 1999
  • Biology, Medicine
  • Journal of Cellular Physiology
  • Clonal cell lines were established from adult rat tibia cells immortalized with SV‐40 large T antigen. One clone (TRAB‐11), in which retinoic acid (RA) induced alkaline phosphatase (AP) activity, was selected for further study. The TRAB‐11 cells express high levels of type I collagen mRNA, type IV collagen, fibronectin, practically no type III collagen, little osteopontin, and no osteocalcin. RA stimulates proliferation of TRAB‐11 cells (starting at 10 pM) and survival (starting at 100 pM… CONTINUE READING
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