Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages.

@article{Manicassamy2009RetinoicAR,
  title={Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages.},
  author={Santhakumar Manicassamy and Bali Pulendran},
  journal={Seminars in immunology},
  year={2009},
  volume={21 1},
  pages={22-7}
}
Dendritic cells (DCs) control the strength and quality of antigen-specific T and B cell responses. Recent advances point to a novel mechanism, in which metabolism of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of lymphocyte differentiation. First, RA enhances the induction of Foxp3(+) T regulatory cells by DCs. Thus, specific… CONTINUE READING