Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.

  title={Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.},
  author={Frank M. J. Jacobs and Jesse V Veenvliet and Wadia H Almirza and Elisa J. Hoekstra and Lars von Oerthel and Annemarie J. A. van der Linden and Roel Neijts and Marian J. A. Groot Koerkamp and Dik van Leenen and Frank C. P. Holstege and J. Peter H. Burbach and Marten P Smidt},
  volume={138 23},
Development of meso-diencephalic dopamine (mdDA) neurons requires the combined actions of the orphan nuclear receptor Nurr1 and the paired-like homeobox transcription factor Pitx3. Whereas all mdDA neurons require Nurr1 for expression of Th and survival, dependence on Pitx3 is displayed only by the mdDA subpopulation that will form the substantia nigra (SNc). Previously, we have demonstrated that Pitx3(-/-) embryos lack the expression of the retinoic acid (RA)-generating enzyme Ahd2, which is… CONTINUE READING
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