Retinoic acid decreases ATF-2 phosphorylation and sensitizes melanoma cells to taxol-mediated growth inhibition

@article{Huang2008RetinoicAD,
  title={Retinoic acid decreases ATF-2 phosphorylation and sensitizes melanoma cells to taxol-mediated growth inhibition},
  author={Ying Che Huang and Jennifer L Minigh and Sarah L. Miles and Richard M. Niles},
  journal={Journal of Molecular Signaling},
  year={2008},
  volume={3},
  pages={3 - 3}
}
Cutaneous melanoma is often resistant to chemo- and radiotherapy. This resistance has recently been demonstrated to be due, at least in part, to high activating transcription factor 2 (ATF-2) activity in these tumors. In concordance with these reports, we found that B16 mouse melanoma cells had higher levels of ATF-2 than immortalized, but non-malignant mouse melanocytes. In addition, the melanoma cells had a much higher amount of phosphorylated (active) ATF-2 than the immortalized melanocytes… CONTINUE READING

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