Retinoic acid availability drives the asynchronous initiation of spermatogonial differentiation in the mouse.

@article{Snyder2010RetinoicAA,
  title={Retinoic acid availability drives the asynchronous initiation of spermatogonial differentiation in the mouse.},
  author={Elizabeth M. Snyder and Christopher L. Small and Michael D Griswold},
  journal={Biology of reproduction},
  year={2010},
  volume={83 5},
  pages={783-90}
}
Throughout the reproductive lifespan of most male mammals, sperm production is constant because of the regulated differentiation of spermatogonia. Retinoic acid (RA) and a downstream target, Stra8, are required for complete spermatogenesis. To examine the role of RA in initiating spermatogonial differentiation, a transgenic mouse model expressing beta-galactosidase under the control of an RA response element was used. Cells in the neonatal testis undergoing active RA signaling were visualized… CONTINUE READING
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