Retinoic acid and substratum regulate the differentiation of rabbit tracheal epithelial cells into squamous and secretory phenotype. Morphological and biochemical characterization.

@article{Jetten1987RetinoicAA,
  title={Retinoic acid and substratum regulate the differentiation of rabbit tracheal epithelial cells into squamous and secretory phenotype. Morphological and biochemical characterization.},
  author={Anton M Jetten and Arnold R. Brody and M A Deas and Gary E. R. Hook and J I Rearick and Scott M. Thacher},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1987},
  volume={56 6},
  pages={
          654-64
        }
}
In this paper we show that the expression of the squamous differentiated phenotype and mucosecretory phenotype by cultured rabbit tracheal epithelial cells can be regulated by substratum and the presence of retinoic acid. Cells grown on a type I collagen gel matrix in the absence of retinoic acid stratify and undergo squamous differentiation as indicated by the appearance of squamous, cornified cells. Under these conditions cells are rich in desmosomes and heavy tonofilament bundles. These… CONTINUE READING
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