Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures.

@article{Takahashi1999RetinoicAA,
  title={Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures.},
  author={Jun Takahashi and Theo D. Palmer and Fred H. Gage},
  journal={Journal of neurobiology},
  year={1999},
  volume={38 1},
  pages={65-81}
}
The adult rat hippocampus contains fibroblast growth factor 2-responsive stem cells that are self-renewing and have the ability to generate both neurons and glia in vitro, but little is known about the molecular events that regulate stem cell differentiation. Hippocampus-derived stem cell clones were used to examine the effects of retinoic acid (RA) on neuronal differentiation. Exposure to RA caused an immediate up-regulation of NeuroD, increased p21 expression, and concurrent exit from cell… CONTINUE READING
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