Retinoic acid and histone deacetylase inhibitor BML-210 inhibit proliferation of human cervical cancer HeLa cells.

@article{Borutinskaite2006RetinoicAA,
  title={Retinoic acid and histone deacetylase inhibitor BML-210 inhibit proliferation of human cervical cancer HeLa cells.},
  author={Veronika Viktorija Borutinskaite and Rūta Navakauskienė and Karl-Eric Magnusson},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1091},
  pages={
          346-55
        }
}
Human papillomavirus (HPV) infection is believed to be the central cause of cervical cancer. The viral proteins E6 and E7 from high-risk HPV types prevent cells from differentiating apoptosis and inducing hyperproliferative lesions. Human cervical carcinoma HeLa cells contain integrated human papillomavirus type 18 (HPV-18). Retinoic acid (RA) is a key regulator of epithelial cell differentiation and a growth inhibitor in vitro of HeLa cervical carcinoma cells. Cellular responses to RA are… CONTINUE READING

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