Retinoic acid and cisdiaminodichloroplatinum in the treatment of murine teratocarcinomas in vivo in a nullipotent model.

@article{Wouda1993RetinoicAA,
  title={Retinoic acid and cisdiaminodichloroplatinum in the treatment of murine teratocarcinomas in vivo in a nullipotent model.},
  author={S Wouda and Bert Timmer and Nanno H. Mulder and Anke Dam and Johan Koudstaal and J Wolter Oosterhuis},
  journal={Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy},
  year={1993},
  volume={13 4},
  pages={261-6}
}
Induction of differentiation as a treatment modality for nonseminomatous germ cell tumors (NSGCTs) may promote the development of residual mature teratoma (RMT), which is usually associated with primary tumors that are capable of spontaneous somatic differentiation. Therefore, we studied the combination of a cytotoxic drug and a differentiation-inducing agent in vivo in three murine teratocarcinoma models with different levels of spontaneous somatic differentiation: E86-379 (moderate… CONTINUE READING