Retinoic acid and VEGF delay smooth muscle relative to endothelial differentiation to coordinate inner and outer coronary vessel wall morphogenesis.

@article{Azambuja2010RetinoicAA,
  title={Retinoic acid and VEGF delay smooth muscle relative to endothelial differentiation to coordinate inner and outer coronary vessel wall morphogenesis.},
  author={Ana P Azambuja and Victor Portillo-S{\'a}nchez and Mariliza Velho Rodrigues and Samantha Vieira Omae and Deborah Schechtman and Bryan E Strauss and Eugenia Costanzi-Strauss and Jos{\'e} Eduardo Krieger and Jos{\'e} M P{\'e}rez-Pomares and Jos{\'e} Xavier-Neto},
  journal={Circulation research},
  year={2010},
  volume={107 2},
  pages={204-16}
}
RATIONALE Major coronary vessels derive from the proepicardium, the cellular progenitor of the epicardium, coronary endothelium, and coronary smooth muscle cells (CoSMCs). CoSMCs are delayed in their differentiation relative to coronary endothelial cells (CoEs), such that CoSMCs mature only after CoEs have assembled into tubes. The mechanisms underlying this sequential CoE/CoSMC differentiation are unknown. Retinoic acid (RA) is crucial for vascular development and the main RA-synthesizing… CONTINUE READING