Retinoic acid and 1,25-dihydroxyvitamin D3 stimulate osteoclast formation by different mechanisms.

@article{Scheven1990RetinoicAA,
  title={Retinoic acid and 1,25-dihydroxyvitamin D3 stimulate osteoclast formation by different mechanisms.},
  author={Ben A. A. Scheven and Nancy J. Hamilton},
  journal={Bone},
  year={1990},
  volume={11 1},
  pages={53-9}
}
The effects of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3 on osteoclast formation were examined in intact fetal long bones of different ages/developmental stages maintained in organ culture using a chemically defined medium with or without the presence of serum. Besides stimulating bone resorption, RA and 1,25-(OH)2D3 increased the number of osteoclasts in 19-day-old fetal rat tibiae. Likewise, these bone-resorbing agents induced and stimulated osteoclast formation in 19- and… CONTINUE READING