Retinoic acid affects basement membrane formation of the seminiferous cords in 14-day male rat gonads in vitro.

@article{Marinos1995RetinoicAA,
  title={Retinoic acid affects basement membrane formation of the seminiferous cords in 14-day male rat gonads in vitro.},
  author={Evangelos Marinos and M Kulukussa and A Zotos and Christos N. Kittas},
  journal={Differentiation; research in biological diversity},
  year={1995},
  volume={59 2},
  pages={87-94}
}
The vitamin A derivative retinoic acid (RA) has been previously shown to have teratogenic effects and an ability to modulate cell differentiation in vivo and in vitro. In this study bilateral testicular primordia with the mesonephroi attached were isolated from rat fetuses at 14.5 days of gestation. The gonads were cultured on agar-coated grids in a synthetic medium. RA was added to male rat embryonic gonad cultures at a final concentration of 10(-6) M for 3 h. Two types of controls were… CONTINUE READING