Retinoic acid X receptor in the diploblast, Tripedalia cystophora.

  title={Retinoic acid X receptor in the diploblast, Tripedalia cystophora.},
  author={Zdeněk Kostrouch and Marta Kostrouchov{\'a} and William G. Love and Emmanuele Angelo Jannini and Joram Piatigorsky and Joseph Edward Rall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 23},
Nuclear hormone receptors comprise a characteristic family of transcription factors found in vertebrates, insects and nematodes. Here we show by cDNA and gene cloning that a Cnidarian, Tripedalia cystophora, possesses a retinoid receptor (jRXR) with remarkable homology to vertebrate retinoic acid X receptors (RXRs). Like vertebrate RXRs, jRXR binds 9-cis retinoic acid (Kd = 4 x 10(-10) M) and binds to the DNA sequence, PuGGTCA as a monomer in vitro. jRXR also heterodimerizes with Xenopus TR… 

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