Retinoic acid X receptor in the diploblast, Tripedalia cystophora.

@article{Kostrouch1998RetinoicAX,
  title={Retinoic acid X receptor in the diploblast, Tripedalia cystophora.},
  author={Zdeněk Kostrouch and Marta Kostrouchov{\'a} and William G. Love and Emmanuele Angelo Jannini and Joram Piatigorsky and Joseph Edward Rall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 23},
  pages={
          13442-7
        }
}
Nuclear hormone receptors comprise a characteristic family of transcription factors found in vertebrates, insects and nematodes. Here we show by cDNA and gene cloning that a Cnidarian, Tripedalia cystophora, possesses a retinoid receptor (jRXR) with remarkable homology to vertebrate retinoic acid X receptors (RXRs). Like vertebrate RXRs, jRXR binds 9-cis retinoic acid (Kd = 4 x 10(-10) M) and binds to the DNA sequence, PuGGTCA as a monomer in vitro. jRXR also heterodimerizes with Xenopus TR… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Steroid/thyroid hormone receptor genes in Caenorhabditis elegans.
TLDR
Cloning three distinct members of the retinoic acid receptor (RAR), thyroid hormone receptor subfamily of genes from the nematode Caenorhabditis elegans demonstrates that the STR family of genes is represented in a nematodes whose ancestor appeared well before the branching that gave rise to the Arthropoda and Chordata. Expand
Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor
TLDR
One gene is described, XR2C, which encodes a product with structural similarity to the human retinoic acid-responsive tran-scription factor, retinoid X receptor, which suggests that similar chemical cues underlie morphogenic signalling in vertebrate and invertebrate systems. Expand
An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens development.
TLDR
It is reported that retinoic acid (RA), a substance known for its teratogenic effects on the eye and as a natural endogenous morphogenetic agent, acts as a regulator of gene expression in the lens. Expand
The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms.
TLDR
It is suggested that the mouse RXR gamma gene may have two promoters, similar to those described for the three RAR genes, and that there may be more than two isoforms of mRXR gamma. Expand
BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.
TLDR
Benzoates comprise a new molecular class of nuclear receptor ligand and their activity suggests that BXR may control a previously unsuspected vertebrate signaling pathway. Expand
J1-crystallins of the cubomedusan jellyfish lens constitute a novel family encoded in at least three intronless genes.
TLDR
Surprisingly, the only obvious similarities among the 5'-flanking regions of the three J1-crystallin genes are putative TATA boxes and several CAAT sequences, consistent with fewer evolutionary constraints on the regulatory sequences than on the coding sequences of these crystallin genes. Expand
The RXR heterodimers and orphan receptors
TLDR
The historical links between the steroid and nonsteroid receptor signaling systems are established, the explosive development of the retinoid X receptor (RXR) heterodimer and orphan receptor family is charted, the impact of these discoveries on the authors' understanding of the mechanisms of hormonal signaling is explained, and emerging issues and implications are presented. Expand
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
TLDR
The identification of a stereoisomer of retinoic acid, 9-cis retinol, which directly binds and activates RXRα, which suggests a new role for isomerization in the physiology of natural retinoids. Expand
Heterodimeric interaction of the retinoic acid and thyroid hormone receptors in transcriptional regulation on the gamma F-crystallin everted retinoic acid response element.
TLDR
In vitro binding studies indicate that RAR/RXR heterodimers form less stable interactions with the gamma F-HRE compared with T3R/R XR heterODimers; this suggests that in vivo the binding affinity of RAR-RXS heterodIMers may be enhanced by accessory factors. Expand
Functional Interactions between Retinoic Acid Receptor-related Orphan Nuclear Receptor (RORα) and the Retinoic Acid Receptors in the Regulation of the γF-Crystallin Promoter (*)
We have previously demonstrated that an everted repeat of the hexamer PuGGTCA located within the γF-crystallin promoter mediates activation of the murine γF-crystallin gene by retinoic acid andExpand
...
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3
4
...