Retinoic acid: its biosynthesis and metabolism.

  title={Retinoic acid: its biosynthesis and metabolism.},
  author={Joseph L Napoli},
  journal={Progress in nucleic acid research and molecular biology},
  • Joseph L Napoli
  • Published 1999 in
    Progress in nucleic acid research and molecular…
This article presents a model that integrates the functions of retinoid-binding proteins with retinoid metabolism. One of these proteins, the widely expressed (throughout retinoid target tissues and in all vertebrates) and highly conserved cellular retinol-binding protein (CRBP), sequesters retinol in an internal binding pocket that segregates it from the intracellular milieu. The CRBP-retinol complex appears to be the quantitatively major form of retinol in vivo, and may protect the… CONTINUE READING


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