Retinoic acid, meiosis and germ cell fate in mammals.

@article{Bowles2007RetinoicAM,
  title={Retinoic acid, meiosis and germ cell fate in mammals.},
  author={Josephine Bowles and Peter Koopman},
  journal={Development},
  year={2007},
  volume={134 19},
  pages={3401-11}
}
Although mammalian sex is determined genetically, the sex-specific development of germ cells as sperm or oocytes is initiated by cues provided by the gonadal environment. During embryogenesis, germ cells in an ovary enter meiosis, thereby committing to oogenesis. By contrast, germ cells in a testicular environment do not enter meiosis until puberty. Recent findings indicate that the key to this sex-specific timing of meiosis entry is the presence or absence of the signaling molecule retinoic… CONTINUE READING
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Sex - specific regulation of retinoic acid levels in developing mouse gonads determines germ cell fate

  • J. Bowles, D. Knight, +7 authors J. Rossant
  • Science
  • 2006
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