Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish

@inproceedings{Mitchell2015RetinoicAS,
  title={Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish},
  author={Diana M Mitchell and Craig B. Stevens and Ruth A. Frey and Samuel S. Hunter and Ryuichi Ashino and Shoji Kawamura and Deborah L. Stenkamp and Claude Desplan},
  booktitle={PLoS genetics},
  year={2015}
}
The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. Here we elucidate the role of RA in differential regulation of the tandemly-duplicated long wavelength-sensitive (LWS) cone opsin genes. Zebrafish embryos were treated with RA from 48 hours post-fertilization (hpf) to 75 hpf, and RNA was isolated from eyes for microarray analysis. ~170 genes showed significantly altered expression, including several transcription factors and… CONTINUE READING

From This Paper

Topics from this paper.
16 Citations
117 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 117 references

The Zebrafish Book; A guide for the laboratory use of zebrafish (Danio rerio)

  • M Westerfield
  • 2007
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…