Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development

@article{Chanda2013RetinoicAS,
  title={Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development},
  author={Bhaskar Chanda and Andrea P Ditadi and Norman N. Iscove and Gordon Keller},
  journal={Cell},
  year={2013},
  volume={155},
  pages={215-227}
}
Hematopoietic stem cells (HSCs) develop from a specialized subpopulation of endothelial cells known as hemogenic endothelium (HE). Although the HE origin of HSCs is now well established in different species, the signaling pathways that control this transition remain poorly understood. Here, we show that activation of retinoic acid (RA) signaling in aorta-gonad-mesonephros-derived HE ex vivo dramatically enhanced its HSC potential, whereas conditional inactivation of the RA metabolizing enzyme… CONTINUE READING
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