Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-Cells

@article{strm2008RetinoicAP,
  title={Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-Cells},
  author={Maria {\"O}str{\"o}m and Kelly A. Loffler and Sara Edfalk and Lars Selander and Ulf L Dahl and Camillo Ricordi and Jongmin Jeon and Mayrin Correa-Medina and Juan P. Diez and Helena Edlund},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={877 - 881}
}
The identification of secreted factors that can selectively stimulate the generation of insulin producing beta-cells from stem and/or progenitor cells represent a significant step in the development of stem cell-based beta-cell replacement therapy. By elucidating the molecular mechanisms that regulate the generation of beta-cells during normal pancreatic development such putative factors may be identified. In the mouse, beta-cells increase markedly in numbers from embryonic day (e) 14.5 and… CONTINUE READING

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