Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.

@article{Calder2015RetinoicAR,
  title={Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.},
  author={Elizabeth Lane Calder and Jason Tchieu and Julius A. Steinbeck and Edmund Y. Tu and Sotirios Keros and Shui-Wang Ying and Manoj K Jaiswal and Daniela Cornacchia and Peter A Goldstein and V Tabar and Lorenz P Studer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 33},
  pages={
          11462-81
        }
}
UNLABELLED The derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of the best defined, directed differentiation strategies to specify fate in pluripotent lineages. In mouse ESCs, MN yield is particularly high after RA + SHH treatment, whereas human ESC (hESC) protocols have been generally less efficient. In an effort to optimize yield, we observe that functional MNs can be derived from hESCs at high efficiencies if… CONTINUE READING
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